22/03/04Abstract
Daraasado badan oo caafimaad ayaa baadhay dib-u-soo-noqoshada heroin-ka iyo kookeynta ee raadinta moodooyinka xayawaanka, laakiin inta badan daraasaddan ayaa baadhay hal daawo oo keliya markiiba. Si kastaba ha ahaatee, balwadaha bini'aadamka, si kastaba ha ahaatee, isticmaalka dawooyinka badan ee kookeynta iyo heroinku waa wax caadi ah. Waxaan u isticmaalnay qaabka dib u soo noqoshada is-maamulka is-maamulka ee jiirka si aan u go'aaminno waxyaabaha ay isku midka yihiin iyo kala duwanaanshaha aagagga maskaxda ee la shaqeysiiyay inta lagu guda jiro dib u soo celinta heroin iyo kookeynta. Guud ahaan, natiijadu waxay tilmaamaysaa in PL ay noqon karto meel maskaxeed oo caadi ah oo ku lug leh labada heroin iyo kookeynta raadinta inta lagu jiro isticmaalka daroogada;
Sidaa darteed, sawirada gobollada Cg1 iyo amygdala (CeA iyo BLA) ayaa si dhijitaal ah loo qabtay iyadoo la adeegsanayoDhyana 400DCkamarad iyo software mosaic ee Windows, nooca 1.4 (Tucsen) ， Aagga sawirka la helay wuxuu ahaa 1.698 mm2 (1.304 mm x1.302 mm).
Jaantuska 1 Dib-u-soo-celinta cocaine-ka ama raadinta heroin-ka waxay la xiriirtaa Fos induction ee PL, laakiin maaha meelaha kale ee kortikal hore (Cg1 iyo IL), oo aan ku jirin striatum ama amygdala.
(a) Tirada Fos-positive nuclei/mm2 (macnaha ± SEM) ee mPFC (Cg1,PL, iyo IL)
(b) dorsal striatum (qayb-hoosaadka dhexe iyo lateral), nucleus accumens (xudunta hoose iyo qolofka), iyo amygdala (CeA iyo BLA hoosaadyada) ee calaamadaha (n = 6-7), cocaine cue (n = 6), iyo heroin cue (n = 6) kooxaha. *p <0.05 marka loo eego kooxda tilmaanta lahayn. Sawirada gobol kasta oo maskaxeed ayaa laga soo qaaday aagagga lagu tilmaamay sanduuqyada madow ee dibedda ee nidaamka qaybta wadnaha. Aagagga muunada gaarka ah ee loo isticmaalo qiyaasidda nukleiyada Fospositive waxaa lagu muujiyay dulsaar midabaysan.
(c) Sawirada matalayaasha nukleiyada Fospositive ee PL iyo IL kortex.
Falanqaynta tignoolajiyada sawirka
Dhyana 400DCkamarad ayaa loo isticmaalay in lagu soo qaado sawirada gobollo kala duwan oo maskaxda ah tijaabadan. Waxa kale oo ay muujisay awoodda sawir-qaadista ee heer-sare ee deegaanka iftiinka hooseeya, taas oo si wax ku ool ah u gaabin karta wakhtiga soo-gaadhista. Cabbirka pixels ee 6.5μm wuxuu si fiican ugu dhigmi karaa mikroskoob-ka, waana mid ka mid ah kamaradaha sayniska ee midabka yar ee suuqa. Natiijooyinka tijaabada ayaa sidoo kale ka caawin doona daraasadda qabatinka bini'aadamka ee heroin iyo kookeynta.
Isha tixraaca
Rubio, FJ, Quintana-Feliciano, R., Warren, BL, Li, X., Witonsky, K., Valle, F., Selvam, PV, Caprioli, D., Venniro, M., Bossert, JM, Shaham, Y., & Hope, BT (2019). Kortexka Prelimbic waa aag maskaxeed oo caadi ah oo la dhaqaajiyay inta lagu guda jiro dib u soo celinta kookeynta iyo heroin-ka ee raadinaya qaabka jiirka is-maamulka ee dawooyinka badan. Joornaalka Yurub ee cilmiga neerfaha, 49(2), 165-178.
